HSV-1 antiviral-resistant corneal isolate#R4
ANTIVIRAL RESISTANT STRAIN
Produced by: ERASMUS-MC
Shipping From: Rotterdam - NL
This isolate belongs to a unique set of HSV-1 isolates cultured from corneal swabs taken from deceased corneas of otherwise healthy immunecompetent patients with a history of recurrent HSV-1 keratitis in The Netherlands. In-vitro susceptibility profile, and thymidine kinase genotype, have been described for acyclovir, ganciclovir and foscarnet.
Product Risk Group:
Viral Storage Medium -80C
Virus host type:
virus stocks generated in Vero cells. Virus production in culture supernatant was tested by HSV-1 specific PCR and HSV-specific immunefluorescence on infected Vero cells.
Production cell line:
Isolate #R4 is both acyclovir- and ganciclovir-resistant, but foscarnet sensitive (see PMID: 19795980)
Information about the collection of the virus
Biological material origin:
Monday, 1 January, 2018
Country of collection:
Suspected epidemiological origin :
virus culture in-vitro
infection of Vero cells with aliquot virus transport medium containing corneal swab.
otherwise healthy immunecompetent patient with recurrent HSV-1 keratitis